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KF-20444

CAT: 0013-GTR19273713-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273713-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KF-20444 is an orally active ALK inhibitor with the ability to penetrate the blood-brain barrier. It exhibits potent inhibitory effects on ALK fusion proteins (EML4-ALK) and ALK-resistant mutations, including L1196M, G1202R, and F1174L. KF-20444 effectively suppresses the phosphorylation of ALK in cancer cell lines driven by ALK, thereby inhibiting cancer cell proliferation and inducing apoptosis (apoptosis) . In mouse models bearing ALK-positive non-small cell lung cancer or neuroblastoma, it demonstrates antitumor efficacy. KF-20444 is applicable for research into ALK-driven malignancies.
CAS Number
154015-73-3
Smiles
O=C (O) C=1C=2C=C (F) C=CC2N=C3C=4C=CC (=CC4CCCC31) C=5C=CC=CC5F
Molecular Formula
C25H17F2NO2
Molecular Weight
401.41
Storage Conditions
-20°C
Notes
For research use only.

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