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SJ 11646

CAT: 0013-GTR19219806Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219806Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJ 11646 is a potent, dasatinib-based PROTAC degrader of lymphocyte-specific protein tyrosine kinase (LCK) with a phenyl glutarimide cereblon binder. It demonstrates potent cytotoxicity in LCK-activated T-ALL cell lines and primary samples in vitro and shows anti-leukemic efficacy in patient-derived xenograft models in vivo, supporting its study in T-cell malignancy research.
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CC1=NC (NC2=NC=C (C (NC3=C (C=CC=C3Cl) C) =O) S2) =CC (N4CCN (CC4) CCCNC (COC5=CC=C (C=C5) C6CCC (NC6=O) =O) =O) =N1
Molecular Formula
C36H40ClN9O5S
Molecular Weight
746.28
Storage Conditions
-20°C
Notes
For research use only.

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