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UM-203

CAT: 0013-GTR19273773-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273773-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UM-203 is a reversible covalent STING antagonist effective against both mouse and human STING. It is particularly potent in inhibiting the common human STINGR232 variant. UM-203 prevents STING oligomerization and decreases the phosphorylation of downstream TBK1 and IRF3, thereby blocking the signaling pathways mediated by IRF3 and NF-κB, and inhibiting the secretion of IFNβ and IL-6. UM-203 is useful for research in inflammation and immunology, such as systemic lupus erythematosus.
Storage Conditions
-20°C
Notes
For research use only.

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