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UM-164

CAT: 0013-GTR19170509-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170509-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UM-164 (DAS-DFGO-II) is a potent, dual-action inhibitor targeting c-Src (Kd=2.7 nM) and p38α/β MAP kinases. This small molecule is a valuable research tool for investigating oncogenic signaling, inflammation, and cellular stress responses in both in vitro and in vivo experimental models.
CAS Number
903564-48-7
Product Name Alternative
C-Src, DAS-DFGO-II, Autophagy, inhibit, Inhibitor, p38α, p38MAPK, p38β, p38 MAPK, Src, UM164, UM-164, UM 164
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
98.72% (May vary between batches)
Solubility
DMSO:6.41 mg/mL (10 mM)
Smiles
Cc1nc (Nc2ncc (s2) C (=O) Nc2cc (NC (=O) c3cccc (c3) C (F) (F) F) ccc2C) cc (n1) N1CCN (CCO) CC1
Molecular Formula
C30H31F3N8O3S
Molecular Weight
640.68
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Das-dfgo-II
CAS Number903564-48-7
PubChem CID11714353
IUPAC Name2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxamide
Molecular FormulaC30H31F3N8O3S
Molecular Weight640.7
XLogP4.7
Topological Polar Surface Area164
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count13
Rotatable Bond Count9
Heavy Atom Count45
Formal Charge0
Complexity991
SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)NC(=O)C3=CN=C(S3)NC4=CC(=NC(=N4)C)N5CCN(CC5)CCO
InChI
InChI=1S/C30H31F3N8O3S/c1-18-6-7-22(37-27(43)20-4-3-5-21(14-20)30(31,32)33)15-23(18)38-28(44)24-17-34-29(45-24)39-25-16-26(36-19(2)35-25)41-10-8-40(9-11-41)12-13-42/h3-7,14-17,42H,8-13H2,1-2H3,(H,37,43)(H,38,44)(H,34,35,36,39)
InChIKey
ANEBQUSWQAQFQB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Das-dfgo-II
CAS: 903564-48-7
CID: 11714353
Formula: C30H31F3N8O3S
MW: 640.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight640.7
XLogP34.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count13
Rotatable Bond Count9
Exact Mass640.21919254
Monoisotopic Mass640.21919254
Topological Polar Surface Area164 Ų
Heavy Atom Count45
Formal Charge0
Complexity991
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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