Hydroxy-α-sanshool (Standard)

Hydroxy-α-sanshool (Standard)

• CAS Number: 83883-10-7
• UNSPSC Description: Hydroxy-α-sanshool (Standard) is the analytical standard of Hydroxy-α-sanshool. This product is intended for research and analytical applications. Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research[1][2].
• Target Antigen: Endogenous Metabolite; TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/hydroxy-α-sanshool-standard.html
• Smiles: C/C=C/C=C/C=C\CC/C=C/C(NCC(C)(O)C)=O
• Molecular Weight: 263.38
• References & Citations: [1]Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.|[2]Koo JY, et al. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 2007 Sep;26(5):1139-47.
• Shipping Conditions: Room temperature