ErSO-TFPy

CAT: 0804-HY-153468-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-153468-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ErSO-TFPy activates the sodium channel TRPM4, causes an imbalance of intracellular calcium and sodium ions. ErSO-TFPy exhibits low nanomolar cytotoxicity in ERĪ±+ breast cancer cell lines (IC50 = 5-25 nM) through induction of necrosis. ErSO-TFPy exhbits antitumor efficacy in mouse models[1].
CAS Number
[3035547-78-2]
UNSPSC
12352005
Target
Sodium Channel; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1[C@@](N2CC(F)(C(F)(C2)F)F)(C3=CC=C(C=C3)O)C4=CC=CC(C(F)(F)F)=C4N1
Molecular Formula
C19H13F7N2O2
Molecular Weight
434.31
References & Citations
[1]Mulligan MP, et al., Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Cent Sci. 2025 Jan 22;11 (2) :228-238.
Shipping Conditions
Room Temperature
Storage Conditions
-20Ā°C, 3 years; 4Ā°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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