ErSO-TFPy

• Description:

  ErSO-TFPy activates the sodium channel TRPM4, causes an imbalance of intracellular calcium and sodium ions. ErSO-TFPy exhibits low nanomolar cytotoxicity in ERα+ breast cancer cell lines (IC50 = 5-25 nM) through induction of necrosis. ErSO-TFPy exhbits antitumor efficacy in mouse models[1].

• UNSPSC:

  12352005

• Target:

  Sodium Channel; TRP Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  99.33

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@@](N2CC(F)(C(F)(C2)F)F)(C3=CC=C(C=C3)O)C4=CC=CC(C(F)(F)F)=C4N1

• Molecular Formula:

  C19H13F7N2O2

• Molecular Weight:

  434.31

• References & Citations:

  [1]Mulligan MP, et al., Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Cent Sci. 2025 Jan 22;11 (2) :228-238.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3035547-78-2]