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Azido-PEG4-CH2-Boc

CAT: 0804-HY-42618-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-42618-01Size:100 mg
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Description
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
864681-04-9
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg4-ch2-boc.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)COCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C14H27N3O6
Molecular Weight
333.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1.|[2]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28 (1) :115228.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers

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