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Hydroxy-PEG4- (CH2) 2-Boc

CAT: 0804-HY-W039178-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W039178-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydroxy-PEG4- (CH2) 2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Hydroxy-PEG4- (CH2) 2-Boc is extracted from patent WO2004008101A2 (compound 191) . Hydroxy-PEG4- (CH2) 2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
CAS Number
518044-32-1
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxy-peg4-ch2-2-boc.html
Purity
99.34
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
Molecular Formula
C15H30O7
Molecular Weight
322.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Qingqi Chen, et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Non-cleavable Linker; PEG Linkers

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