Hydroxy-PEG4- (CH2) 2-Boc

• Description:

  Hydroxy-PEG4- (CH2) 2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Hydroxy-PEG4- (CH2) 2-Boc is extracted from patent WO2004008101A2 (compound 191) . Hydroxy-PEG4- (CH2) 2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hydroxy-peg4-ch2-2-boc.html

• Purity:

  99.34

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC(C)(C)C)CCOCCOCCOCCOCCO

• Molecular Formula:

  C15H30O7

• Molecular Weight:

  322.39

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Qingqi Chen, et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Alkyl/ether Linkers; Non-cleavable Linker; PEG Linkers

• CAS Number:

  [518044-32-1]