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Azido-PEG4- (CH2) 3OH

CAT: 0804-HY-140809-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140809-01Size:50 mg
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Description
Azido-PEG4- (CH2) 3OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4- (CH2) 3OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2028281-87-8
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg4-ch2-3oh.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
OCCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C11H23N3O5
Molecular Weight
277.32
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-PEG4-(CH2)3OH
CAS Number2028281-87-8
PubChem CID123132068
IUPAC Name3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propan-1-ol
Molecular FormulaC11H23N3O5
Molecular Weight277.32
XLogP0.2
Topological Polar Surface Area71.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count15
Heavy Atom Count19
Formal Charge0
Complexity224
SMILES
C(CO)COCCOCCOCCOCCN=[N+]=[N-]
InChI
InChI=1S/C11H23N3O5/c12-14-13-2-5-17-7-9-19-11-10-18-8-6-16-4-1-3-15/h15H,1-11H2
InChIKey
GGAFKPLUTSFPET-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG4-(CH2)3OH
CAS: 2028281-87-8
CID: 123132068
Formula: C11H23N3O5
MW: 277.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight277.32
XLogP30.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count15
Exact Mass277.16377084
Monoisotopic Mass277.16377084
Topological Polar Surface Area71.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity224
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-140630-01Ald-CH2-PEG4-Boc
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Alternative Products

CatalogName
BA2504-500Azido-PEG4-CH2-Boc
MBS5768536Azido-PEG4-(CH2)3OH
T14447-01Azido-PEG4- (CH2) 3OH
T14446-01Azido-PEG4-(CH2)3-methyl ester
KYC75971Azido-PEG4- (CH2) 3-methyl ester
572452Azido-PEG3-(CH2)3OH
HXC51236-01Azido-PEG3- (CH2) 3OH
T14274-01Aminooxy-PEG4-CH2-Boc
T15530-01Hydroxy-PEG4-CH2-Boc
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