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MA191

CAT: 0013-GTR19264576-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264576-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MA191 is an FLT3 PROTAC degrader that effectively addresses FLT3 inhibitor resistance caused by the rebound activation of mitogen-activated kinases. It rapidly degrades FLT3-ITD via a mechanism involving VHL, Neddylation, and BIM, reducing FLT3-ITD levels prior to inducing apoptosis. Moreover, MA191 inhibits the proliferation of AML cells in zebrafish and is applicable for acute myeloid leukemia (AML) research.
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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CatalogName
HY-175273MA191

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