Products for Research Use Only
RegisterLogin

MA191

CAT: 0931-T212387-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T212387-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
HSP, Apoptosis, PROTACs, FLT, Akt, ERK, STAT
Related Pathways
Tyrosine Kinase/Adaptors, Metabolism, Apoptosis, PROTAC, Angiogenesis, MAPK, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Stem Cells
Bioactivity
MA191 is an FLT3 PROTAC degrader that effectively addresses FLT3 inhibitor resistance caused by the rebound activation of mitogen-activated kinases. It rapidly degrades FLT3-ITD via a mechanism involving VHL, Neddylation, and BIM, reducing FLT3-ITD levels prior to inducing apoptosis. Moreover, MA191 inhibits the proliferation of AML cells in zebrafish and is applicable for acute myeloid leukemia (AML) research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-175273MA191

Popular Products