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COX-2-IN-55

CAT: 0013-GTR19263644-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263644-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC) . Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.
CAS Number
2649115-80-8
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction
Smiles
O=S (=O) (NC=1C=CC=C (N) C1) C2=CC=C (C=C2) N3N=C (C=C3C=4C=C (C=CC4C) C) C (F) (F) F
Molecular Formula
C24H21F3N4O2S
Molecular Weight
486.51
Storage Conditions
-20°C
Notes
For research use only.

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