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CDK-IN-18

CAT: 0013-GTR19263624-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263624-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant, and selective inhibitor of CDK2, CDK4, and CDK6. It hinders the activity of cyclin-CDK complexes, preventing the phosphorylation of retinoblastoma protein (pRb), and thereby blocks the transition of cells from the G1 phase to the S phase. CDK-IN-18 shows potential for cancer research, such as in breast cancer (particularly hormone receptor-positive, HER2-negative types), lung cancer, and colorectal cancer.
CAS Number
2531743-46-9
Field of Research
Cell Biology
Smiles
C (C) (C) C1=C2N (C=CC (=C2) C3=NC (NC4=CC=C (C=N4) N5C (=O) C[C@@H] (N (C) C) CC5) =NC=C3) N=C1
Molecular Formula
C26H30N8O
Molecular Weight
470.57
Storage Conditions
-20°C
Notes
For research use only.

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