Products for Research Use Only
RegisterLogin

Keap1-IN-2

CAT: 0013-GTR19263464-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19263464-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Keap1-IN-2 (Compound 164) is an inhibitor of KEAP1 with an IC50 of 2 nM. It indirectly activates Nrf2 by blocking KEAP1, thereby enhancing cellular antioxidant capacity. By preventing KEAP1-mediated degradation of Nrf2, Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2. This compound is used in research on diseases related to oxidative stress, such as inflammatory bowel disease, Crohn's disease, and ulcerative colitis, which are immune-related conditions.
CAS Number
3066895-41-5
Field of Research
Cancer Biology, Immunology & Inflammation
Smiles
C (C) (=O) N1[C@@H] (CN (C (C=C) =O) C[C@H]1C) C=2C=C (N=C (Cl) C2) C=3C=C (C (NC) =O) N=CN3
Molecular Formula
C21H23ClN6O3
Molecular Weight
442.90
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-[4-[(2R,6R)-1-acetyl-6-methyl-4-prop-2-enoylpiperazin-2-yl]-6-chloro-2-pyridinyl]-N-methylpyrimidine-4-carboxamide
CAS Number3066895-41-5
PubChem CID176126726
IUPAC Name6-[4-[(2R,6R)-1-acetyl-6-methyl-4-prop-2-enoylpiperazin-2-yl]-6-chloro-2-pyridinyl]-N-methylpyrimidine-4-carboxamide
Molecular FormulaC21H23ClN6O3
Molecular Weight442.9
XLogP1
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity707
SMILES
C[C@@H]1CN(C[C@H](N1C(=O)C)C2=CC(=NC(=C2)Cl)C3=CC(=NC=N3)C(=O)NC)C(=O)C=C
InChI
InChI=1S/C21H23ClN6O3/c1-5-20(30)27-9-12(2)28(13(3)29)18(10-27)14-6-16(26-19(22)7-14)15-8-17(21(31)23-4)25-11-24-15/h5-8,11-12,18H,1,9-10H2,2-4H3,(H,23,31)/t12-,18+/m1/s1
InChIKey
LFACUFPMARNBSP-XIKOKIGWSA-N
Chemical Structure
2D Structure
2D structure of 6-[4-[(2R,6R)-1-acetyl-6-methyl-4-prop-2-enoylpiperazin-2-yl]-6-chloro-2-pyridinyl]-N-methylpyrimidine-4-carboxamide
CAS: 3066895-41-5
CID: 176126726
Formula: C21H23ClN6O3
MW: 442.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight442.9
XLogP31
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass442.1520163
Monoisotopic Mass442.1520163
Topological Polar Surface Area108 Ų
Heavy Atom Count31
Formal Charge0
Complexity707
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19274249-01Keap1/Nrf2/ARE activator 2
GTR18234299-01KEAP1 Antibody
GTR18226087KEAP1 Antibody
GTR18101193KEAP1 Antibody
GTR18912799KEAP1 Peptide
GTR18592681-01KEAP1 Antibody
GTR18588212-01KEAP1 Antibody
GTR18587279-01KEAP1 Antibody
GTR19250045-01Keap1-IN-1
GTR19058293KEAP1 Peptide

Alternative Products

CatalogName
HY-174287Keap1-IN-2
sc-365626Keap1 (G-2)
sc-365626 HRPKeap1 (G-2) HRP
538249-01Keap1
sc-365626 PEKeap1 (G-2) PE
sc-365626 ACKeap1 (G-2) AC
sc-365626 FITCKeap1 (G-2) FITC
YP-W13339-01Human KEAP1 (KEAP1) ELISA Kit
TMAB-01018-01Anti-KEAP1 Polyclonal Antibody 2
MBS6012144-01KEAP1, CT (KEAP1,INRF2, KIAA0132, KLHL19)

Popular Products