DEG-35

CAT: 0013-GTR19257927-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19257927-02Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML) .

CAS Number

2734910-37-1

Field of Research

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Smiles

O=C (NC1=CC=C2C (=O) N (CC2=C1) C3C (=O) NC (=O) CC3) C4=CC=C5C=C (OC) C=CC5=C4

Molecular Formula

C25H21N3O5

Molecular Weight

443.45

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-6-methoxynaphthalene-2-carboxamide

CAS Number	2734910-37-1
PubChem CID	166819388
IUPAC Name	N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]-6-methoxynaphthalene-2-carboxamide
Molecular Formula	C25H21N3O5
Molecular Weight	443.5
XLogP	2.2
Topological Polar Surface Area	105
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	33
Formal Charge	0
Complexity	816

SMILES

COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NC3=CC4=C(C=C3)C(=O)N(C4)C5CCC(=O)NC5=O

InChI

InChI=1S/C25H21N3O5/c1-33-19-6-4-14-10-16(3-2-15(14)12-19)23(30)26-18-5-7-20-17(11-18)13-28(25(20)32)21-8-9-22(29)27-24(21)31/h2-7,10-12,21H,8-9,13H2,1H3,(H,26,30)(H,27,29,31)

InChIKey

JGWFFKIYBDZDFI-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2734910-37-1

CID: 166819388

Formula: C25H21N3O5

MW: 443.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	443.5
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	443.14812078
Monoisotopic Mass	443.14812078
Topological Polar Surface Area	105 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	816
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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