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CDK12-IN-8

CAT: 0013-GTR19257749-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257749-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK12-IN-8 (Compound Cpd143) is an orally active, highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . It blocks the phosphorylation of serine 2 in the C-terminal domain (CTD) of RNA polymerase II, thereby interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 holds potential for research in cancers with high CDK12 expression, such as small cell lung cancer and triple-negative breast cancer.
CAS Number
2928619-86-5
Field of Research
Cell Biology, Signal Transduction
Smiles
N ([C@H]1C[C@@H] (C=2N3C (=NN2) C=C (C#N) C=C3) CCC1) C=4N=C (OC5COC5) C (C (F) (F) F) =CN4
Molecular Formula
C21H20F3N7O2
Molecular Weight
459.42
Storage Conditions
-20°C
Notes
For research use only.

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