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SIK2-IN-3

CAT: 0013-GTR19258479-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258479-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.
CAS Number
2810809-10-8
Field of Research
Cell Biology, Signal Transduction
Smiles
O (C[C@@H]1CCN (C) C1) C=2C (=CC (C#N) =NC2) C3=CC=4N (C=C3) N=C (NC (=O) C5CC5) C4
Molecular Formula
C23H24N6O2
Molecular Weight
416.48
Storage Conditions
-20°C
Notes
For research use only.

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