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SIK2-IN-4

CAT: 0804-HY-171591-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171591-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC50s 0.143 and 0.076 μM, respectively) . SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB) -dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC50: 0.11 µM), IL-12/23 p40 (IC50: 0.25 µM), and IL-23 (IC50: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases[1].
CAS Number
2810810-00-3
UNSPSC
12352005
Target
Interleukin Related; Salt-inducible Kinase (SIK) ; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Infection
Smiles
N#CC1=CC(C2=CC3=CC(NC(C4CC4)=O)=NN3C=C2)=C(OC5CN(C5)C)C=N1
Molecular Formula
C21H20N6O2
Molecular Weight
388.42
References & Citations
[1]Babbe H, et al. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc Natl Acad Sci U S A. 2024 Jan 2;121 (1) :e2307086120.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-23; SIK1; SIK2

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