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AZ3246

CAT: 0013-GTR19249713-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249713-01Size:50 mg
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Description
AZ3246 is a potent and selective oral HPK1 inhibitor with sub-3 nM IC50, promoting IL-2 secretion in T cells (EC50 = 90 nM) . This low-clearance compound is utilized in immuno-oncology research to study T-cell activation and antitumor responses in both cellular and in vivo models.
CAS Number
2893978-54-4
Field of Research
Immunology & Inflammation, Signal Transduction
Smiles
O=C (N) C1=NC (=C (N=C1NC2=CN (N=C2C) CC (F) (F) F) C3CC3) C4=CN=CC5=C4N=CN5C
Molecular Formula
C21H20F3N9O
Molecular Weight
471.438
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 166485054
CAS Number2893978-54-4
PubChem CID166485054
IUPAC Name5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide
Molecular FormulaC21H20F3N9O
Molecular Weight471.4
XLogP1.9
Topological Polar Surface Area129
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity753
SMILES
CC1=NN(C=C1NC2=NC(=C(N=C2C(=O)N)C3=CN=CC4=C3N=CN4C)C5CC5)CC(F)(F)F
InChI
InChI=1S/C21H20F3N9O/c1-10-13(7-33(31-10)8-21(22,23)24)28-20-18(19(25)34)29-17(15(30-20)11-3-4-11)12-5-26-6-14-16(12)27-9-32(14)2/h5-7,9,11H,3-4,8H2,1-2H3,(H2,25,34)(H,28,30)
InChIKey
YLGMPWWMPCGYBF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 166485054
CAS: 2893978-54-4
CID: 166485054
Formula: C21H20F3N9O
MW: 471.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass471.17429078
Monoisotopic Mass471.17429078
Topological Polar Surface Area129 Ų
Heavy Atom Count34
Formal Charge0
Complexity753
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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