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AZ304

CAT: 0013-GTR19160705-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160705-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ304 is a novel potent, dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF and wild type CRAF with IC50 of 79 nM, 38 nM and 68 nM, respectively; also potentlt inhibits p38 and CSF1R with IC50 of 6 and 35 nM, has no activity for MAP3K7, CSK, IGF1R, EGFR, FGFR, CDK2, CDK4, JAK2, SRC (IC50>5 uM) ; potently reduces p-ERK with mean EC50 of 65 nM in the V600E mutant BRAF containing melanoma cell line A375, EC50 of 60 nM in wild type BRAF melanoma cell line SK-MEL-31; inhibits cell proliferation in mutant BRAF, wt BRAF/RAS and mutant RAS with IC50 of 0.08-7.72 uM, 0.43-11.7 uM 0.9-16.66 uM, respectively; Cetuximab enhances the potency of AZ304 independently of BRAF mutational status in vivo.
CAS Number
942507-42-8
Product Name Alternative
AZ 304 | AZ-304
Purity
>98% (HPLC)
Solubility
DMSO: 85 mg/mL; Ethanol: 4 mg/mL; Water: Insoluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NC1=CC=C (C) C (NC2=C3C=CC (OC) =CC3=NC=N2) =C1) C4=CC=CC (C (C) (C#N) C) =C4
Molecular Formula
C27H25N5O2
Molecular Weight
451.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (2-cyanopropan-2-yl) -N- (3- ((7-methoxyquinazolin-4-yl) amino) -4-methylphenyl) benzamide

Alternative Products

CatalogName
BA3649-100AZ304
A17225-100AZ304 100mg
A17225-50AZ304 50mg
A17225-10AZ304 10mg
A17225-25AZ304 25mg
A17225-5AZ304 5mg
A17225-10mM-DAZ304 10mM * 1mL in DMSO

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