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AZ32

CAT: 0013-GTR19170217-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170217-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ32 is a potent, orally bioavailable, and brain-penetrant small molecule inhibitor of ATM kinase. It demonstrates high enzymatic inhibition (IC50 <6.2 nM) and cellular activity (IC50 = 0.31 μM) . This inhibitor is a valuable tool for investigating ATM's role in DNA damage response, cancer research, and in vivo studies of central nervous system malignancies.
CAS Number
2288709-96-4
Product Name Alternative
Inhibitor, inhibit, AZ 32, ATR, ATM/ATR, ATM, ATM and RAD3 related, Ataxia telangiectasia mutated, AZ32, AZ-32
Field of Research
Molecular Biology, Signal Transduction
Purity
98.68% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.09 mM) ; DMSO:55 mg/mL (167.49 mM)
Smiles
CNC (=O) c1ccc (cc1) -c1cnc2cnc (cn12) -c1ccccc1
Molecular Formula
C20H16N4O
Molecular Weight
328.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
CAS Number2288709-96-4
PubChem CID134814488
IUPAC NameN-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
Molecular FormulaC20H16N4O
Molecular Weight328.4
XLogP3.3
Topological Polar Surface Area59.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity457
SMILES
CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=CC=C4
InChI
InChI=1S/C20H16N4O/c1-21-20(25)16-9-7-15(8-10-16)18-11-23-19-12-22-17(13-24(18)19)14-5-3-2-4-6-14/h2-13H,1H3,(H,21,25)
InChIKey
LCRTUEXVVKVKBD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
CAS: 2288709-96-4
CID: 134814488
Formula: C20H16N4O
MW: 328.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight328.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass328.13241115
Monoisotopic Mass328.13241115
Topological Polar Surface Area59.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity457
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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