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AG-024322

CAT: 0804-HY-15491-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15491-01Size:1 mg
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Description
AG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range[1]. AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation in vivo. AG-024322 induces cell apoptosis[3].
CAS Number
837364-57-5
UNSPSC
12352005
Target
Apoptosis; COX
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ag-024322.html
Purity
98.53
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(CNCC)C=NC=C1C2=CC3=C(NN=C3C4=NC5=CC(F)=CC(F)=C5N4)C=C2
Molecular Formula
C23H20F2N6
Molecular Weight
418.44
References & Citations
[1]Brown AP, et al. Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion.Cancer Chemother Pharmacol. 2008 Nov;62 (6) :1091-101.|[2]Jessen BA, et al. Peripheral white blood cell toxicity induced by broad spectrum cyclin-dependent kinase inhibitors.J Appl Toxicol. 2007 Mar-Apr;27 (2) :133-42.|[3]Cathy C. Zhang, et al. AG-024322 is a multi-targeted CDK inhibitor with potent antitumor activity in vivo. Cellular and Molecular Biology 53: Cell Cycle Control and Cancer 1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
COX-1; COX-2

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