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RI-1

CAT: 0013-GTR19174055-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174055-01Size:5 mg
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Description
RI-1 is a small molecule inhibitor of the RAD51 recombinase, exhibiting inhibitory activity with an IC50 in the 5-30 μM range. It is utilized in research to study DNA repair mechanisms, particularly homologous recombination, and has been applied in both cellular and biochemical assays to investigate cancer biology and potential therapeutic strategies.
CAS Number
415713-60-9
Product Name Alternative
RAD51 inhibitor 1, RAD51, recombination, RI 1, RI1, RI-1, RNA Synthesis, RNASynthesis, DNA Synthesis, DNASynthesis, inhibit, Inhibitor, homologous
Field of Research
Cell Biology
Purity
>98%
Bioactivity
RAD51 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming) .
Smiles
ClC1=C (N2CCOCC2) C (=O) N (C1=O) c1ccc (Cl) c (Cl) c1
Molecular Formula
C14H11Cl3N2O3
Molecular Weight
361.61
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3-Chloro-1- (3,4-dichlorophenyl) -4- (4-morpholinyl) -1H-pyrrole-2,5-dione

Chemical Information

3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

an inhibitor of RAD51 that disrupts homologous recombination in human cells; structure in first source

CAS Number415713-60-9
PubChem CID1074953
IUPAC Name3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
Molecular FormulaC14H11Cl3N2O3
Molecular Weight361.6
XLogP3.1
Topological Polar Surface Area49.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity519
SMILES
C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl
InChI
InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2
InChIKey
MWSUIZKGNWELRF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
CAS: 415713-60-9
CID: 1074953
Formula: C14H11Cl3N2O3
MW: 361.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight361.6
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass359.983525
Monoisotopic Mass359.983525
Topological Polar Surface Area49.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity519
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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