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EAPB-0503

CAT: 0013-GTR19241697-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241697-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EAPB-0503 is an imidazoquinoxaline analog of Imiquimod that selectively downregulates HDM2 and activates p53 in NPM1c-expressing cells, leading to apoptosis. This mechanism supports its investigation in vitro and in vivo for cancers driven by NPM1 mutations, such as acute myeloid leukemia (AML) .
CAS Number
1140627-77-5
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction
Smiles
N=1C=C (C2=CC=CC (OC) =C2) N3C1C (=NC=4C=CC=CC43) NC
Molecular Formula
C18H16N4O
Molecular Weight
304.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Eapb-0503

antineoplastic; structure in first source

CAS Number1140627-77-5
PubChem CID25253256
IUPAC Name1-(3-methoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine
Molecular FormulaC18H16N4O
Molecular Weight304.3
XLogP4.1
Topological Polar Surface Area51.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity406
SMILES
CNC1=NC2=CC=CC=C2N3C1=NC=C3C4=CC(=CC=C4)OC
InChI
InChI=1S/C18H16N4O/c1-19-17-18-20-11-16(12-6-5-7-13(10-12)23-2)22(18)15-9-4-3-8-14(15)21-17/h3-11H,1-2H3,(H,19,21)
InChIKey
PLJRXCRNKAGLBD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Eapb-0503
CAS: 1140627-77-5
CID: 25253256
Formula: C18H16N4O
MW: 304.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass304.13241115
Monoisotopic Mass304.13241115
Topological Polar Surface Area51.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity406
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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