EAPB 02303

• Description :

  EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations[1].

• CAS Number :

  [1958290-51-1]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Microtubule/Tubulin; Mitosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/eapb-02303.html

• Purity :

  98.05

• Solubility :

  H2O : 30 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC(C=C1)=C(O)C=C1C2=CN=C3C(NC)=NC4=CC=CC=C4N32

• Molecular Formula :

  C17H14N4O2

• Molecular Weight :

  306.32

• References & Citations :

  [1]Bigot K, et al. Imiqualines for pancreatic cancer: first-in-class potent and synergistic inhibitors of microtubule polymerisation[J]. Cancer Research, 2023, 83 (7_Supplement) : 5729-5729.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported