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ALT-007

CAT: 0013-GTR19249284-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249284-02Size:50 mg
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Description
ALT-007 is an orally active small molecule inhibitor of serine palmitoyltransferase (SPT), the key enzyme in ceramide biosynthesis. It has been shown to reverse age-related muscle loss and dysfunction in murine models of sarcopenia and to improve protein homeostasis in aging studies using C. elegans and mouse models.
CAS Number
2035010-37-6
Field of Research
Metabolism Research
Smiles
O=C (NC1C2=C (C=NN2C (C) C) N (C (=O) C3=CN=C (OC) C (OC) =C3) CC1) C=4C=CC=CC4OC (F) (F) F
Molecular Formula
C25H26F3N5O5
Molecular Weight
533.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(4-(5,6-Dimethoxynicotinoyl)-1-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)-2-(trifluoromethoxy)benzamide
CAS Number2035010-37-6
PubChem CID134278627
IUPAC NameN-[4-(5,6-dimethoxypyridine-3-carbonyl)-1-propan-2-yl-6,7-dihydro-5H-pyrazolo[4,5-b]pyridin-7-yl]-2-(trifluoromethoxy)benzamide
Molecular FormulaC25H26F3N5O5
Molecular Weight533.5
XLogP3.3
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count38
Formal Charge0
Complexity834
SMILES
CC(C)N1C2=C(C=N1)N(CCC2NC(=O)C3=CC=CC=C3OC(F)(F)F)C(=O)C4=CC(=C(N=C4)OC)OC
InChI
InChI=1S/C25H26F3N5O5/c1-14(2)33-21-17(31-22(34)16-7-5-6-8-19(16)38-25(26,27)28)9-10-32(18(21)13-30-33)24(35)15-11-20(36-3)23(37-4)29-12-15/h5-8,11-14,17H,9-10H2,1-4H3,(H,31,34)
InChIKey
MOKGQUKWOUYHHS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-(5,6-Dimethoxynicotinoyl)-1-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)-2-(trifluoromethoxy)benzamide
CAS: 2035010-37-6
CID: 134278627
Formula: C25H26F3N5O5
MW: 533.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight533.5
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass533.18860343
Monoisotopic Mass533.18860343
Topological Polar Surface Area108 Ų
Heavy Atom Count38
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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