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ONO-7579

CAT: 0013-GTR19239064-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239064-02Size:50 mg
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Description
ONO-7579 is a potent and orally bioavailable TRKA inhibitor that suppresses tumor growth by blocking TRKA phosphorylation. It demonstrates in vivo efficacy, with an EC50 of 17.6 ng/g in KM12 colorectal cancer xenograft models, making it a valuable tool for investigating TRKA-driven cancers in preclinical research.
CAS Number
1622212-25-2
Field of Research
Signal Transduction
Smiles
O=C (NC1=CN=C (N=C1) OC=2C=CC (=CC2) C3=CC (Cl) =CN=C3N) NC4=CC (=CC=C4S (=O) (=O) C) C (F) (F) F
Molecular Formula
C24H18ClF3N6O4S
Molecular Weight
578.95
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ono-7579

Pan-TRK Inhibitor ONO-7579 is an orally bioavailable, selective pan-tropomyosin-related-kinase (tyrosine receptor kinase; TRK) inhibitor, with potential antineoplastic activity. Upon oral administration, ONO-7579 specifically targets and binds to TRK and fusion proteins containing sequences from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1; TrkA), 2 (NTRK2; TrkB), and 3 (NTRK3; TrkC). This inhibits neurotrophin-TRK interaction and TRK activation, thereby preventing the activation of downstream signaling pathways and resulting in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress TRK and/or express NTRK fusion proteins. TRK, a family of receptor tyrosine kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes.The expression of either mutated forms of, or fusion proteins involving, NTRK family members results in uncontrolled TRK signaling, which plays an important role in tumor cell growth, survival, invasion and treatment resistance.

CAS Number1622212-25-2
PubChem CID78322573
IUPAC Name1-[2-[4-(2-amino-5-chloro-3-pyridinyl)phenoxy]pyrimidin-5-yl]-3-[2-methylsulfonyl-5-(trifluoromethyl)phenyl]urea
Molecular FormulaC24H18ClF3N6O4S
Molecular Weight579.0
XLogP4.1
Topological Polar Surface Area158
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count6
Heavy Atom Count39
Formal Charge0
Complexity926
SMILES
CS(=O)(=O)C1=C(C=C(C=C1)C(F)(F)F)NC(=O)NC2=CN=C(N=C2)OC3=CC=C(C=C3)C4=C(N=CC(=C4)Cl)N
InChI
InChI=1S/C24H18ClF3N6O4S/c1-39(36,37)20-7-4-14(24(26,27)28)8-19(20)34-22(35)33-16-11-31-23(32-12-16)38-17-5-2-13(3-6-17)18-9-15(25)10-30-21(18)29/h2-12H,1H3,(H2,29,30)(H2,33,34,35)
InChIKey
GYPOVJZOMXEUDO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ono-7579
CAS: 1622212-25-2
CID: 78322573
Formula: C24H18ClF3N6O4S
MW: 579.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight579.0
XLogP34.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count6
Exact Mass578.0750864
Monoisotopic Mass578.0750864
Topological Polar Surface Area158 Ų
Heavy Atom Count39
Formal Charge0
Complexity926
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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