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AP14145

CAT: 0013-GTR19237745-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19237745-01Size:10 mg
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Description
AP14145 is a selective small molecule inhibitor of small conductance calcium-activated potassium channels KCa2.2 and KCa2.3 (IC50 = 1.1 μM) . It exhibits antiarrhythmic properties by prolonging the atrial effective refractory period and has been shown to convert atrial fibrillation to sinus rhythm in preclinical porcine models of heart dysfunction.
CAS Number
1446770-54-2
Smiles
N (C (C) =O) C1=C2C (N=C (N[C@H] (C) C3=CC (C (F) (F) F) =CC=C3) N2) =CC=C1
Molecular Formula
C18H17F3N4O
Molecular Weight
362.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[2-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-4-yl]acetamide
CAS Number1446770-54-2
PubChem CID71657103
IUPAC NameN-[2-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-4-yl]acetamide
Molecular FormulaC18H17F3N4O
Molecular Weight362.3
XLogP3.8
Topological Polar Surface Area69.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity501
SMILES
C[C@H](C1=CC(=CC=C1)C(F)(F)F)NC2=NC3=C(N2)C=CC=C3NC(=O)C
InChI
InChI=1S/C18H17F3N4O/c1-10(12-5-3-6-13(9-12)18(19,20)21)22-17-24-15-8-4-7-14(16(15)25-17)23-11(2)26/h3-10H,1-2H3,(H,23,26)(H2,22,24,25)/t10-/m1/s1
InChIKey
NLXYWXWZVMFJQS-SNVBAGLBSA-N
Chemical Structure
2D Structure
2D structure of N-[2-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-4-yl]acetamide
CAS: 1446770-54-2
CID: 71657103
Formula: C18H17F3N4O
MW: 362.3
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight362.3
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass362.13544566
Monoisotopic Mass362.13544566
Topological Polar Surface Area69.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-120355AP14145
T39963AP14145 hydrochloride
HY-120355AAP14145 (hydrochloride)

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