AP14145

CAT: 0804-HY-120355Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-120355Size:1 Each

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Description

AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect[1][2].

CAS Number

1446770-54-2

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ap14145.html

Smiles

CC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O

Molecular Formula

C18H17F3N4O

Molecular Weight

362.35

References & Citations

[1]Citerni C, et al., Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction. Front Pharmacol. 2020 May 6;11:556.|[2]Simó-Vicens R, et al., A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels. Br J Pharmacol. 2017 Dec;174 (23) :4396-4408.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19237745-01	AP14145
T39963	AP14145 hydrochloride

AP14145

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