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AP14145

CAT: 0931-T89598-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89598-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1446770-54-2
Bioactivity
AP14145 functions as an inhibitor of the small conductance calcium-activated potassium channels (small conductance calcium-activated potassium channel), specifically blocking the KCa2.2 channel (KCa2.2 channel) and KCa2.3 channel (KCa2.3 channel) with an IC50 of 1.1 μM for both. It prolongs the atrial effective refractory period (AERP) in rats and has been shown to convert atrial fibrillation to sinus rhythm in a porcine model of left ventricular dysfunction, demonstrating antiarrhythmic properties.
Smiles
N(C(C)=O)C1=C2C(N=C(N[C@H](C)C3=CC(C(F)(F)F)=CC=C3)N2)=CC=C1
Molecular Formula
C18H17F3N4O
Molecular Weight
362.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-120355AP14145
MBS5800328AP14145 hydrochloride
HY-120355AAP14145 (hydrochloride)

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