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JG-23

CAT: 0013-GTR19231066-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19231066-02Size:5 mg
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Description
JG-23 is a 4-chloro-modified small molecule that promotes the degradation of tau protein (t-tau) . It exhibits promising metabolic stability with a 36-minute half-life in mouse liver microsomes, supporting its potential for in vitro and in vivo neurodegenerative disease research.
CAS Number
2640819-75-4
Field of Research
Signal Transduction
Smiles
CN1/C (/SC=2C1=CC (Cl) =CC2) =C\3/C (=O) N (CC) \C (=C\C=4C=CN=CC4) \S3
Molecular Formula
C19H16ClN3OS2
Molecular Weight
401.93
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 164625273
CAS Number2640819-75-4
PubChem CID164625273
IUPAC Name(2Z,5E)-5-(5-chloro-3-methyl-1,3-benzothiazol-2-ylidene)-3-ethyl-2-(pyridin-4-ylmethylidene)-1,3-thiazolidin-4-one
Molecular FormulaC19H16ClN3OS2
Molecular Weight401.9
XLogP4.5
Topological Polar Surface Area87
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count26
Formal Charge0
Complexity632
SMILES
CCN1/C(=C/C2=CC=NC=C2)/S/C(=C/3\N(C4=C(S3)C=CC(=C4)Cl)C)/C1=O
InChI
InChI=1S/C19H16ClN3OS2/c1-3-23-16(10-12-6-8-21-9-7-12)26-17(18(23)24)19-22(2)14-11-13(20)4-5-15(14)25-19/h4-11H,3H2,1-2H3/b16-10-,19-17+
InChIKey
LIWXAIDHVWIEQV-SRNIGAPGSA-N
Chemical Structure
2D Structure
2D structure of CID 164625273
CAS: 2640819-75-4
CID: 164625273
Formula: C19H16ClN3OS2
MW: 401.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.9
XLogP34.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass401.0423322
Monoisotopic Mass401.0423322
Topological Polar Surface Area87 Ų
Heavy Atom Count26
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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