Products for Research Use Only
RegisterLogin

JG-48

CAT: 0013-GTR19197431-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19197431-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JG-48 is a small molecule Hsp70 inhibitor that reduces both phosphorylated and total Tau protein levels in cellular models, including endogenous Tau in neuroblastoma cells. This compound is a useful research tool for studying tauopathies, such as Alzheimer's disease, in both in vitro and in vivo experimental systems.
CAS Number
1627122-26-2
Field of Research
Metabolism Research, Signal Transduction
Smiles
CN1/C (/SC=2C1=CC=C (C (F) (F) F) C2) =C\3/C (=O) N (CC) \C (=C\C4=CC=CC=N4) \S3
Molecular Formula
C20H16F3N3OS2
Molecular Weight
435.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(2Z,5E)-3-ethyl-5-[3-methyl-6-(trifluoromethyl)-1,3-benzothiazol-2-ylidene]-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one
CAS Number1627122-26-2
PubChem CID78323930
IUPAC Name(2Z,5E)-3-ethyl-5-[3-methyl-6-(trifluoromethyl)-1,3-benzothiazol-2-ylidene]-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one
Molecular FormulaC20H16F3N3OS2
Molecular Weight435.5
XLogP4.8
Topological Polar Surface Area87
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Heavy Atom Count29
Formal Charge0
Complexity724
SMILES
CCN1/C(=C/C2=CC=CC=N2)/S/C(=C/3\N(C4=C(S3)C=C(C=C4)C(F)(F)F)C)/C1=O
InChI
InChI=1S/C20H16F3N3OS2/c1-3-26-16(11-13-6-4-5-9-24-13)29-17(18(26)27)19-25(2)14-8-7-12(20(21,22)23)10-15(14)28-19/h4-11H,3H2,1-2H3/b16-11-,19-17+
InChIKey
AWHRSRSTZWQWDX-PZCBVGOASA-N
Chemical Structure
2D Structure
2D structure of (2Z,5E)-3-ethyl-5-[3-methyl-6-(trifluoromethyl)-1,3-benzothiazol-2-ylidene]-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one
CAS: 1627122-26-2
CID: 78323930
Formula: C20H16F3N3OS2
MW: 435.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight435.5
XLogP34.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass435.06868898
Monoisotopic Mass435.06868898
Topological Polar Surface Area87 Ų
Heavy Atom Count29
Formal Charge0
Complexity724
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19231066-01JG-23
GTR19220973-01JG-258
GTR19163172-01JG-98
GTR19168515-01JG-98
GTR19218345-01JG-2016
GTR19209629-01JG-231
GTR19200187JG 365
GTR1802695448 Antibody
GTR19238883-01NLRP3-IN-48
GTR19235191-01HSD17B13-IN-48

Alternative Products

CatalogName
MBS5777364JG-48
HY-130366JG-365
T70353-01JG-231
T78533-01JG-23
sc-507517JG-98
E5885-01JG-2016
T24199JG 365

Popular Products