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UC-764864

CAT: 0013-GTR19230690-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19230690-01Size:1 mg
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Description
UC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, reducing UBE2N ubiquitination. It inhibits innate immune signaling and demonstrates cytotoxic effects in MDS/AML cell lines and primary cells, making it a valuable tool for leukemia research.
CAS Number
278806-03-4
Product Name Alternative
E3Enzyme, E3 Enzyme, E2Enzyme, E2 Enzyme, E1Enzyme, E1 Enzyme, UBE2N
Field of Research
Protein Biochemistry
Purity
99.30% (May vary between batches)
Solubility
DMSO:100 mg/mL (310.15 mM)
Smiles
O=C (C=CSC1=NC=2C=C (C=CC2N1) C) C3=CC=C (C=C3) CC
Molecular Formula
C19H18N2OS
Molecular Weight
322.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(4-Ethylphenyl)-3-((5-methyl-1H-benzo[d]imidazol-2-yl)thio)prop-2-en-1-one
CAS Number278806-03-4
PubChem CID2825864
IUPAC Name1-(4-ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)sulfanyl]prop-2-en-1-one
Molecular FormulaC19H18N2OS
Molecular Weight322.4
XLogP5
Topological Polar Surface Area71.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity431
SMILES
CCC1=CC=C(C=C1)C(=O)C=CSC2=NC3=C(N2)C=C(C=C3)C
InChI
InChI=1S/C19H18N2OS/c1-3-14-5-7-15(8-6-14)18(22)10-11-23-19-20-16-9-4-13(2)12-17(16)21-19/h4-12H,3H2,1-2H3,(H,20,21)
InChIKey
OEFOUCPCKSVCJM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-Ethylphenyl)-3-((5-methyl-1H-benzo[d]imidazol-2-yl)thio)prop-2-en-1-one
CAS: 278806-03-4
CID: 2825864
Formula: C19H18N2OS
MW: 322.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight322.4
XLogP35
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass322.11398438
Monoisotopic Mass322.11398438
Topological Polar Surface Area71.1 Ų
Heavy Atom Count23
Formal Charge0
Complexity431
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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