Products for Research Use Only
RegisterLogin

UC-1728

CAT: 0013-GTR19157246-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19157246-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver) . Rabbits were treated by subcutaneous injection with the sEH inhibitor (UC1728, 3 mg/kg), or the vehicle control (PEG400) and uveitis was assessed at 6, 24 and 48 h post-intracameral LPS injection using a modified Hackett-McDonald scoring system. Eyes treated by intra-cameral injection of PBS, or by aseptic preparation served as further controls. Signs of inflammation in this model were mild and transient. Treatment with UC1728 did not significantly reduce inflammation compared to animals treated with the PEG400 vehicle. Blood levels of UC1728 were a thousand fold higher than the in vitro determined inhibitory potency (IC50) of the compound suggesting a significant degree of inhibition of sEH in the rabbit. The lack of efficacy suggests that sEH or its substrates the EETs may not be involved in mediating inflammation in this model of uveitis.
CAS Number
948304-40-3
Product Name Alternative
T-TUCB
Purity
>98% (HPLC)
Smiles
FC (F) (F) OC (C=C1) =CC=C1NC (N[C@@H] (CC2) CC[C@H]2OC3=CC=C (C (O) =O) C=C3) =O
Molecular Formula
C21H21F3N2O5
Molecular Weight
438.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19209336-01UC-773587
GTR19231831UC-764865
GTR19202955-01UC-112
GTR19273618-01UC-38
GTR19230690-01UC-764864
GTR19175535-01UC-514321
GTR19273637-01UC-84
GTR19210726-01UC-857993
GTR19196265-01UC-781
GTR19187452-01UC-1V150

Alternative Products

CatalogName
BA7689-100UC-1728
A16887-50UC-1728 50mg
A16887-100UC-1728 100mg
A16887-10UC-1728 10mg
A16887-500UC-1728 500mg
A16887-25UC-1728 25mg
A16887-5UC-1728 5mg
A16887-2UC-1728 2mg
BA7395-5UC-764864
HY-124514UC-857993

Popular Products