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TD-139

CAT: 0013-GTR19163189-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163189-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TD-139 (TD139) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM; reduces TGF-β1-induced β-catenin translocation to the nucleus, blocks β-catenin phosphorylation in vitro and in vivo; attenuates the late-stage progression of lung fibrosis in murine models; attenuates liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4 (+) T cells, increases IL-10-producing CD4 (+) T cells and F4/80 (+) CD206 (+) alternatively activated macrophages and prevents the apoptosis of liver-infiltrating MNCs in WT C57BL/6 mice.Cystic Fibrosis, Phase 2 Clinical
CAS Number
1450824-22-2
Product Name Alternative
TD139 | TD 139
Purity
>98% (HPLC)
Solubility
DMSO: 1 mg/mL (Need ultrasonic) ; H2O: < 5 mg/mL; Ethanol: 0.1 mg/mL (Need ultrasonic and warming)
Smiles
O[C@H] ([C@@H] (N1N=NC (C2=CC=CC (F) =C2) =C1) [C@H] ([C@@H] (CO) O3) O) [C@@H]3S[C@H]4[C@@H] ([C@@H] (N5N=NC (C6=CC=CC (F) =C6) =C5) [C@H] ([C@@H] (CO) O4) O) O
Molecular Formula
C28H30F2N6O8S
Molecular Weight
648.635
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
β-D-Galactopyranoside, 3-deoxy-3-[4- (3-fluorophenyl) -1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4- (3-fluorophenyl) -1H-1,2,3-triazol-1-yl]-1-thio-

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