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SIK-IN-2

CAT: 0013-GTR19234638-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234638-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIK-IN-2 (Compound 45) is a highly potent, pan-SIK inhibitor with single-digit nanomolar IC50 values against SIK1, SIK2, and SIK3. It modulates macrophage cytokine profiles by potently suppressing TNFα and enhancing LPS-induced IL-10 release, making it a valuable tool for studying SIK signaling in inflammation and immunometabolism in cellular models.
CAS Number
3033846-20-4
Field of Research
Epigenetics & Chromatin, Signal Transduction
Smiles
C (#N) C=1N2C (=CN=C2C=CC1N) C3=CC (OCC4 (N) CCCC4) =C (C#N) C (SC) =C3
Molecular Formula
C22H22N6OS
Molecular Weight
418.52
Storage Conditions
-20°C
Notes
For research use only.

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