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22- (4′-py) -JA

CAT: 0013-GTR19230450-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19230450-01Size:50 mg
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Description
22- (4′-py) -JA is a semisynthetic junamycin A derivative that demonstrates potent antimetastatic activity, particularly against NSCLC. It functions by inhibiting the AKT/mTOR/p70S6K pathway, thereby suppressing tumor cell invasion, angiogenesis, and the expression of key proteins like MMP-2, MMP-9, HIF-1α, and VEGF in models such as HUVECs.
CAS Number
1178895-15-2
Field of Research
Signal Transduction
Smiles
C (OC (=O) C=1C=CN=CC1) [C@@H]2N3[C@] ([C@]4 (C5=C (C[C@@] ([C@@H]3C#N) (N4C) [H]) C (=O) C (C) =C (OC) C5=O) [H]) (CC6=C2C (=O) C (OC) =C (C) C6=O) [H]
Molecular Formula
C32H30N4O8
Molecular Weight
598.6
Storage Conditions
-20°C
Notes
For research use only.

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