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PY-60

CAT: 0013-GTR19164730-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164730-01Size:1 mg
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Description
PY-60 is a small molecule activator of YAP with a binding affinity (Kd) of 1.4 μM for annexin A2 (ANXA2) . It induces a YAP-dependent transcriptional program that promotes cellular proliferation, as demonstrated in studies of epidermal remodeling in adult animal models. This compound is a valuable research tool for investigating Hippo pathway signaling in both in vitro and in vivo contexts.
CAS Number
2765218-56-0
Product Name Alternative
AnnexinA, Annexin A, Annexin A2, YAP, PY60, PY 60, PY-60
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
98.86% (May vary between batches)
Solubility
DMSO:100 mg/mL (319.11 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.76 mM)
Smiles
C (NCCCC1=NC=CS1) (=O) C=2C=C (ON2) C3=CC=CC=C3
Molecular Formula
C16H15N3O2S
Molecular Weight
313.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-Phenyl-N-(3-(thiazol-2-yl)propyl)isoxazole-3-carboxamide
CAS Number2765218-56-0
PubChem CID155387479
IUPAC Name5-phenyl-N-[3-(1,3-thiazol-2-yl)propyl]-1,2-oxazole-3-carboxamide
Molecular FormulaC16H15N3O2S
Molecular Weight313.4
XLogP3
Topological Polar Surface Area96.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity363
SMILES
C1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCC3=NC=CS3
InChI
InChI=1S/C16H15N3O2S/c20-16(18-8-4-7-15-17-9-10-22-15)13-11-14(21-19-13)12-5-2-1-3-6-12/h1-3,5-6,9-11H,4,7-8H2,(H,18,20)
InChIKey
UFASECSYKSMYET-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Phenyl-N-(3-(thiazol-2-yl)propyl)isoxazole-3-carboxamide
CAS: 2765218-56-0
CID: 155387479
Formula: C16H15N3O2S
MW: 313.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight313.4
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass313.08849790
Monoisotopic Mass313.08849790
Topological Polar Surface Area96.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity363
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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