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CL2 Linker

CAT: 0013-GTR19225742-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19225742-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CL2 linker is a cleavable ADC linker used to conjugate SN-38. The resulting CL2-SN-38 and CL2A-SN-38 conjugates demonstrate equivalent high drug loading, nanomolar binding affinity and cytotoxicity, and good serum stability in vitro, making them valuable tools for ADC research and preclinical development.
CAS Number
2270986-66-6
Field of Research
Pharmacology & Drug Discovery
Smiles
[C@H] (CC1=CC=CC=C1) (C (N[C@H] (C (NC2=CC=C (COC (N (CCN (C (OCC (CO) =O) =O) C) C) =O) C=C2) =O) CCCCNC (OC (C) (C) C) =O) =O) NC (CCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C (CNC (CCCCCN4C (=O) C=CC4=O) =O) N=N3) =O
Molecular Formula
C68H103N11O22
Molecular Weight
1426.61
Storage Conditions
-20°C
Notes
For research use only.

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