SJFα

CAT: 0013-GTR19224984-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19224984-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SJFα is a PROTAC molecule designed to selectively degrade p38α and p38δ isoforms. It functions by recruiting an E3 ubiquitin ligase to tag these kinases for proteasomal destruction. This tool compound is used in cancer research to study p38 signaling in both cellular and in vivo models.

CAS Number

2254609-27-1

Product Name Alternative

Autophagy, p38δ, p38δ:299 nM (DC50), p38α, p38α:7.16 nM (DC50), p38MAPK, p38 MAPK, SJFα, SJF alpha, SJF α, SJFa, SJFalpha, PROTAC, VHL

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

95.25% (May vary between batches)

Solubility

DMSO:80 mg/mL (71.41 mM)

Smiles

C (NC1=CC (F) =C (OC=2C3=C (C=C (OCCCCOCCCCOCC (N[C@H] (C (=O) N4[C@H] (C (NCC5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4) [C@] (C) (C) C) =O) C (OC) =C3) N=CC2) C=C1) (=O) C7 (C (NC8=CC=C (F) C=C8) =O) CC7

Molecular Formula

C59H67F2N7O11S

Molecular Weight

1120.27

Storage Conditions

-20°C

Notes

For research use only.

Alternative Products

Catalog	Name
EQD60923-01	Sjfδ
HY-114404-01	SJFα
533622	SJFÎ±
BA6374-1	SJF-1521
HY-131864-01	SJF-1528
462864	SJF 1528
463067	SJF-8240
7464/5	SJF 0661
T36246	SJF 8240
T36244	SJF 1521

SJFα

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