HL-8

CAT: 0013-GTR19221382-02Size: 50 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19221382-02Size:50 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

HL-8 is a potent PROTAC that induces complete degradation of PI3K at 10 μM within 8 hours. This mechanism demonstrates utility for probing PI3K-dependent signaling pathways in cancer research, supporting both in vitro cellular studies and in vivo preclinical investigations.

CAS Number

2766352-64-9

Field of Research

Signal Transduction

Smiles

COc1ncc (cc1NS (=O) (=O) c1ccc (F) cc1F) -c1ccc2ncc (-c3nnc (o3) -c3ccccc3C (=O) NCCCCCCC (=O) N[C@H] (C (=O) N3C[C@@H] (O) C[C@@H]3C (=O) NCc3ccc (cc3) -c3scnc3C) C (C) (C) C) n2c1

Molecular Formula

C57H59F2N11O9S2

Molecular Weight

1144.27

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

(2R,4S)-1-[(2S)-2-[7-[[2-[5-[6-[5-[(2,4-difluorophenyl)sulfonylamino]-6-methoxy-3-pyridinyl]imidazo[1,2-a]pyridin-3-yl]-1,3,4-oxadiazol-2-yl]benzoyl]amino]heptanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

CAS Number	2766352-64-9
PubChem CID	163408778
IUPAC Name	(2R,4S)-1-[(2S)-2-[7-[[2-[5-[6-[5-[(2,4-difluorophenyl)sulfonylamino]-6-methoxy-3-pyridinyl]imidazo[1,2-a]pyridin-3-yl]-1,3,4-oxadiazol-2-yl]benzoyl]amino]heptanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular Formula	C57H59F2N11O9S2
Molecular Weight	1144.3
XLogP	7.4
Topological Polar Surface Area	302
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	22
Heavy Atom Count	81
Formal Charge	0
Complexity	2210

SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@H]3C[C@@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCNC(=O)C4=CC=CC=C4C5=NN=C(O5)C6=CN=C7N6C=C(C=C7)C8=CC(=C(N=C8)OC)NS(=O)(=O)C9=C(C=C(C=C9)F)F)O

InChI

InChI=1S/C57H59F2N11O9S2/c1-33-49(80-32-64-33)35-17-15-34(16-18-35)27-62-52(74)44-26-39(71)31-70(44)56(75)50(57(2,3)4)65-48(72)14-8-6-7-11-23-60-51(73)40-12-9-10-13-41(40)53-66-67-55(79-53)45-29-61-47-22-19-36(30-69(45)47)37-24-43(54(78-5)63-28-37)68-81(76,77)46-21-20-38(58)25-42(46)59/h9-10,12-13,15-22,24-25,28-30,32,39,44,50,68,71H,6-8,11,14,23,26-27,31H2,1-5H3,(H,60,73)(H,62,74)(H,65,72)/t39-,44+,50+/m0/s1

InChIKey

ACMMTSCGBPIHNT-RMNSFAHDSA-N

Chemical Structure

2D Structure

CAS: 2766352-64-9

CID: 163408778

Formula: C57H59F2N11O9S2

MW: 1144.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1144.3
XLogP3	7.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	22
Exact Mass	1143.39067117
Monoisotopic Mass	1143.39067117
Topological Polar Surface Area	302 Å²
Heavy Atom Count	81
Formal Charge	0
Complexity	2210
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
GTR19262242-01	HL-2
GTR19261184-01	HL-PEG2k
GTR18077330	HL antibody
GTR17956957	PAM71-HL Antibody
GTR19331669	HL Assay Kit (Microanalysis)
GTR19331658	HL Assay Kit (Visible Spectrophotometry)
GTR19267142-01	Nitto Phase HL UnyLinker 300
GTR18851286-01	Human Hepatic lipase (HL) ELISA Kit
GTR18852268-01	Mouse Hepatic lipase (HL) ELISA Kit
GTR18204996-01	HL-60 Antigen / Human Leukemia Antigen Antibody

Alternative Products

Catalog	Name
T74258-01	HL-8
YP-W22585-01	Mouse α-HL (α-HL) ELISA Kit
RWT-1028	HL 60/ HL-60 Cell Line
HY-142533	HL-PEG2k
HY-143277	HL-2
ARC0298	HL-60
E58P1088	Serpin Hl
EHC21803	HL 010183
ARI0058	HL-1
GZ3821-5000U	HL-Nuclease

HL-8

Chemical Information

Related Products

Alternative Products

Popular Products