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PF15

CAT: 0013-GTR19221381-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19221381-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF15 is a potent and selective PROTAC degrader of FLT3-ITD with a DC50 of 76.7 nM. It effectively inhibits proliferation and downstream signaling (FLT3/p-STAT5) in FLT3-ITD-positive cells and suppresses tumor growth in mouse models, highlighting its utility for targeted leukemia research.
CAS Number
2892631-70-6
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
NC1=C2C (=CN (CCCCC3=CN (CCCCC (NC4=C5C (C (=O) N (C5) C6C (=O) NC (=O) CC6) =CC=C4) =O) N=N3) C2=NC=N1) C7=CC=C (NC (NC=8C=C (C (C) (C) C) ON8) =O) C=C7
Molecular Formula
C44H49N13O6
Molecular Weight
855.94
Storage Conditions
-20°C
Notes
For research use only.

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