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PF15

CAT: 0013-GTR19221381-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19221381-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF15 is a potent and selective PROTAC degrader of FLT3-ITD with a DC50 of 76.7 nM. It effectively inhibits proliferation and downstream signaling (FLT3/p-STAT5) in FLT3-ITD-positive cells and suppresses tumor growth in mouse models, highlighting its utility for targeted leukemia research.
CAS Number
2892631-70-6
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
NC1=C2C (=CN (CCCCC3=CN (CCCCC (NC4=C5C (C (=O) N (C5) C6C (=O) NC (=O) CC6) =CC=C4) =O) N=N3) C2=NC=N1) C7=CC=C (NC (NC=8C=C (C (C) (C) C) ON8) =O) C=C7
Molecular Formula
C44H49N13O6
Molecular Weight
855.94
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-[4-[4-[4-amino-5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]butyl]triazol-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentanamide
CAS Number2892631-70-6
PubChem CID165412666
IUPAC Name5-[4-[4-[4-amino-5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]butyl]triazol-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentanamide
Molecular FormulaC44H49N13O6
Molecular Weight855.9
XLogP3.1
Topological Polar Surface Area250
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count16
Heavy Atom Count63
Formal Charge0
Complexity1630
SMILES
CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN(C4=NC=NC(=C34)N)CCCCC5=CN(N=N5)CCCCC(=O)NC6=CC=CC7=C6CN(C7=O)C8CCC(=O)NC8=O
InChI
InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-6-4-9-28-22-56(54-52-28)20-7-5-12-36(58)49-32-11-8-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h8,10-11,13-16,21-23,25,33H,4-7,9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)
InChIKey
BQDQZCCNJKVYDD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-[4-[4-[4-amino-5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]butyl]triazol-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentanamide
CAS: 2892631-70-6
CID: 165412666
Formula: C44H49N13O6
MW: 855.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight855.9
XLogP33.1
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count16
Exact Mass855.39287633
Monoisotopic Mass855.39287633
Topological Polar Surface Area250 Ų
Heavy Atom Count63
Formal Charge0
Complexity1630
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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