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STING Agonist D61

CAT: 0013-GTR19219867-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219867-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D61 is a potent STING agonist with EC50 values of 52.9 nM and 116 nM for inducing IFN-β and SEAP reporter activity in vitro. It activates the TBK1-IRF3 pathway in monocytes and demonstrates in vivo antitumor efficacy in a CT26 colon cancer model at 0.25 mg/kg without weight loss.
CAS Number
2850251-27-1
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology
Smiles
COC1=C2C (N=C (NC (C3=CC (C) =NN3CC) =O) N2CCCNC4=NC=C (C5=C (C (F) (F) F) C=CC=C5) O4) =CC (C (N) =O) =C1
Molecular Formula
C29H29F3N8O4
Molecular Weight
610.60
Storage Conditions
-20°C
Notes
For research use only.

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