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GNE-6640

CAT: 0013-GTR19217372-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217372-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM) ; promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors; decreased viability of 108 cell lines with IC50 <10 uM. (In Vitro) :GNE-6640 promotes endogenous MDM2 ubiquitination with Lys48 (K48) -linked polyubiquitin chains, which directs proteasomal degradation13. GNE-6640 targets cellular USP7, MDM2, and p53 signalling pathways. GNE-6640 decreases viability of 108 cell lines with IC50 ≤ 10 μM. Combining GNE-6640 with doxorubicin or cisplatin (DNA-damaging agents), which could activate the p53 response and enhance USP7 inhibitor efficacy. GNE-6640 could induce tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.
CAS Number
2009273-67-8
Product Name Alternative
GNE 6640 | GNE6640
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OC1=CC=C (C2=C (CC) C (C3=CC4=C (NN=C4) C=C3) =CN=C2N) C=C1
Molecular Formula
C20H18N4O
Molecular Weight
330.391
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[2-Amino-4-ethyl-5- (1H-indazol-5-yl) -3-pyridyl]phenol

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Alternative Products

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T5461-01GNE-6640
A16883-50GNE-6640 50mg
A16883-10GNE-6640 10mg
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A16883-1GNE-6640 1mg
A16883-100GNE-6640 100mg
A16883-5GNE-6640 5mg
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