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MP07-66

CAT: 0013-GTR19216344-07Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216344-07Size:500 mg
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Description
MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells. (In Vitro) :CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation.
CAS Number
1938056-90-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (772.87 mM)
Smiles
CCCCCCOc1ccc (CNCC (OCC) OCC) cc1
Molecular Formula
C19H33NO3
Molecular Weight
323.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

2,2-Diethoxy-N-(4-(hexyloxy)benzyl)ethanamine
CAS Number1938056-90-6
PubChem CID154113489
IUPAC Name2,2-diethoxy-N-[(4-hexoxyphenyl)methyl]ethanamine
Molecular FormulaC19H33NO3
Molecular Weight323.5
XLogP4.2
Topological Polar Surface Area39.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count14
Heavy Atom Count23
Formal Charge0
Complexity249
SMILES
CCCCCCOC1=CC=C(C=C1)CNCC(OCC)OCC
InChI
InChI=1S/C19H33NO3/c1-4-7-8-9-14-23-18-12-10-17(11-13-18)15-20-16-19(21-5-2)22-6-3/h10-13,19-20H,4-9,14-16H2,1-3H3
InChIKey
WBCMPXCRPPCZSO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2,2-Diethoxy-N-(4-(hexyloxy)benzyl)ethanamine
CAS: 1938056-90-6
CID: 154113489
Formula: C19H33NO3
MW: 323.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.5
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count14
Exact Mass323.24604391
Monoisotopic Mass323.24604391
Topological Polar Surface Area39.7 Ų
Heavy Atom Count23
Formal Charge0
Complexity249
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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