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MP07-66

CAT: 0013-GTR19216344-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19216344-01Size:1 g
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Description
MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells. (In Vitro) :CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation.
CAS Number
1938056-90-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (772.87 mM)
Smiles
CCCCCCOc1ccc (CNCC (OCC) OCC) cc1
Molecular Formula
C19H33NO3
Molecular Weight
323.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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