Products for Research Use Only
RegisterLogin

AZD8186

CAT: 0013-GTR19213725-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19213725-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZD8186
CAS Number
1296270-45-5
Notes
For research use only.

Chemical Information

8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

AZD8186 is a member of the class of chromones that is chromone substituted by morpholin-4-yl, dimethylaminoacyl, and (1R)-1-(3,5-difluoroanilino)ethyl groups at positions 2, 6, and 8, respectively. It is a potent inhibitor of PI3K-beta (IC50 = 4nM) and PI3K-delta (IC50 = 12nM) with selectivity over PI3K-alpha (IC50 = 35 nM) and PI3K-gamma (IC50 = 675 nM). It has a role as an antineoplastic agent and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a tertiary carboxamide, a member of chromones, a difluorobenzene, a member of morpholines, a substituted aniline and a secondary amino compound.

CAS Number1296270-45-5
PubChem CID52913929
IUPAC Name8-[1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
Molecular FormulaC24H25F2N3O4
Molecular Weight457.5
XLogP3
Topological Polar Surface Area71.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity748
SMILES
CC(C1=CC(=CC2=C1OC(=CC2=O)N3CCOCC3)C(=O)N(C)C)NC4=CC(=CC(=C4)F)F
InChI
InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3
InChIKey
LMJFJIDLEAWOQJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
CAS: 1296270-45-5
CID: 52913929
Formula: C24H25F2N3O4
MW: 457.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight457.5
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass457.18131261
Monoisotopic Mass457.18131261
Topological Polar Surface Area71.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity748
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19213328AZD8154
GTR19168097-01AZD0156
GTR19211608-01AZD1386
GTR19195491-01AZD8165
GTR19195487-01AZD8926

Alternative Products

CatalogName
MBS384287-01AZD8186
A15759-25AZD8186 25mg
A15759-5AZD8186 5mg
A14164-10AZD8186 10mg
A15759-100AZD8186 100mg
HY-108958(Rac) -AZD8186
A15759-500AZD8186 500mg
A15759-50AZD8186 50mg
A15759-2AZD8186 2mg

Popular Products