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AZD0156

CAT: 0013-GTR19168097-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168097-01Size:1 mg
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Description
AZD0156 is a potent and selective ATM kinase inhibitor with potential antineoplastic activity. It functions as a chemo- and radio-sensitizer in research, with studies demonstrating its utility in vitro and in vivo for investigating DNA damage response pathways in oncology.
CAS Number
1821428-35-6
Product Name Alternative
Apoptosis, AZD0156, AZD-0156, ATR, ATM and RAD3 related, ATM, ATM/ATR, Ataxia telangiectasia mutated, AZD 0156, inhibit, Inhibitor
Field of Research
Cell Biology, Molecular Biology, Signal Transduction
Purity
99.03% (May vary between batches)
Solubility
DMSO:1 mg/mL (2.17 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
CN (C) CCCOc1ccc (cn1) -c1ccc2ncc3n (C) c (=O) n (C4CCOCC4) c3c2c1
Molecular Formula
C26H31N5O3
Molecular Weight
461.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Azd-0156

ATM Kinase Inhibitor AZD0156 is an orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair.

CAS Number1821428-35-6
PubChem CID118502708
IUPAC Name8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one
Molecular FormulaC26H31N5O3
Molecular Weight461.6
XLogP2.9
Topological Polar Surface Area71
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity687
SMILES
CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4CCOCC4)C5=CN=C(C=C5)OCCCN(C)C
InChI
InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3
InChIKey
AOTRIQLYUAFVSC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-0156
CAS: 1821428-35-6
CID: 118502708
Formula: C26H31N5O3
MW: 461.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.6
XLogP32.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass461.24268987
Monoisotopic Mass461.24268987
Topological Polar Surface Area71 Ų
Heavy Atom Count34
Formal Charge0
Complexity687
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T6770-01AZD0156
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A16419-10AZD0156 10mg
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HY-100016RAZD0156 (Standard)
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