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Phenidone

CAT: 0013-GTR19217113-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19217113-01Size:1 g
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Description
Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. (In Vitro) :Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE. (In Vivo) :Lipoxygenase inhibitor phenidone markedly attenuates angiotensin II (AII) induced vascular contractility. Phenidone was also shown to inhibit the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.
CAS Number
92-43-3
Product Name Alternative
1-phenyl-3-pyrazolidinone
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (616.56 mM)
Smiles
OC1=NN (CC1) c1ccccc1
Molecular Formula
C9H10N2O
Molecular Weight
162.192
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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