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Phenidone (Standard)

CAT: 0804-HY-W010144R-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W010144R-02Size:50 mg
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Description
Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
CAS Number
92-43-3
UNSPSC
12352005
Target
COX; Lipoxygenase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C1NN(C2=CC=CC=C2)CC1
Molecular Formula
C9H10N2O
Molecular Weight
162.19
References & Citations
[1]Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035 (2) :206-210.|[2]Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6 (1) :52-58.|[3]Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16 (12) :1583-1587.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Phenidone

photographic developer; RN given refers to parent cpd; structure

CAS Number92-43-3
PubChem CID7090
IUPAC Name1-phenylpyrazolidin-3-one
Molecular FormulaC9H10N2O
Molecular Weight162.19
XLogP0.9
Topological Polar Surface Area32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count12
Formal Charge0
Complexity175
SMILES
C1CN(NC1=O)C2=CC=CC=C2
InChI
InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
InChIKey
CMCWWLVWPDLCRM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Phenidone
CAS: 92-43-3
CID: 7090
Formula: C9H10N2O
MW: 162.19
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight162.19
XLogP30.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass162.079312947
Monoisotopic Mass162.079312947
Topological Polar Surface Area32.3 Ų
Heavy Atom Count12
Formal Charge0
Complexity175
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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